Research Interests: Walter Jessen
Overview
As a Computational Biologist, I am interested in leveraging computational and bioinformatic approaches to study the molecular mechanisms underlying the etiology of disease. My focus is not only on data analysis but data integration — merging information mined from the biomedical literature together with experimental information from a variety of biological systems (e.g. gene, microRNA and protein expression) and tissues (e.g. normal tissue, blood, surrounding tissue, diseased tissue). Founded on the principle that the whole is greater than the sum of its parts, the goal of such integration is to provide a broader understanding of the signals and mechanisms regulating disease development and progression, as well as to inform and guide decision making in the research space.
My interests extend beyond biology to include network science, text mining and data analytics. I am very interested in the use of internet technologies to enhance scientific collaboration, the development of a networked science culture, and the advancement of open source science.
For a summary of educational, academic and business backgrounds, please see Walter Jessen’s curriculum vitae.
Walter Jessen’s publications
Journal Articles
2011
Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Collins MH, Ratner N, Largaespada DA. Conditional Inactivation of Pten and Nf1 in Schwann Cells Results in a Severe Peripheral Nervous System Phenotype and Transformation. Submitted.
Jessen WJ, Miller SJ, Patel AV, Wu J, Rizvi TA, Hardiman A, Niwa-Kawakita M, Page GP, Giovannini M, Aronow BJ, Serra E, Ratner N. Cross-species Transcriptome Analysis of Neurofibroma and MPNST Highlights Suppression of MAPK Signaling and AURKA as a Therapeutic Target in MPNST. Submitted.
Comstock CES, Augello MA, Schiewer MJ, Karch J, Burd CJ, Ertel A, Knudsen ES, Jessen WJ, Aronow BJ, Knudsen KE. JBC. Cyclin D1 is a Selective Modifier of Androgen-dependent Signaling and Androgen Receptor Function. J Biol Chem. 2011 Jan 5. [Epub ahead of print]
2010
Hummel TR, Jessen WJ, Miller SJ, Kluwe L, Mautner VF, Wallace MR, Lazaro C, Page GP, Worley PF, Aronow BJ, Schorry EK, Ratner N. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clin Cancer Res. 2010 Oct 15;16(20):5048-57. Epub 2010 Aug 25. PDF
2009
*Miller SJ, *Jessen WJ, Mehta T, Hardiman A, Sites E, Kaiser S, Jegga A, Li H, Upadhyaya M, Giovannini M, Muir D, Wallace MR, Lopez E, Serra E, Nielsen GP, Lazaro C, Stemmer-Rachamimov A, Page G, Aronow BJ and Ratner N. Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. *These authors contributed equally to this work. EMBO Mol Med 2009, 1(4):236-248. PDF
2008
Shen H, Powers N, Saini N, Comstock CE, Sharma A, Weaver K, Revelo MP, Gerald W, Williams E, Jessen WJ, Aronow BJ, Rossen G, Weissman B, Murchardt C, Yaniv M and Knudsen KE. The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer. Cancer Res 2008, 68(24):10154-10162. PDF
Ouyang X, Jessen WJ, Al-Ahmadie H, Serio AM, Lin Y, Shih WJ, Reuter VE, Scardino PT, Shen MM, Aronow BJ, Vickers AJ, Gerald WL and Abate-Shen C. Activator protein-1 transcription factors are associated with progression and recurrence of prostate cancer. Cancer Res 2008, 68(7):2132-2144. PDF
2007
Banach-Petrosky W, Jessen WJ, Ouyang X, Gao H, Rao J, Quinn J, Aronow BJ and Abate-Shen C. Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; Pten mutant mice. Cancer Res 2007, 67(19):9089-9096. PDF
Liu X, Jessen WJ, Sivaganesan S, Aronow BJ and Medvedovic M. Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data. BMC Bioinformatics 2007, 8:283. PDF
Kaiser S, Park Y, Franklin J, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga A, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Roberts RB, Bissahoyo AC, Gonzales F, Bloom G, Eschrich S, Aronow J, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Levy S, Graff JM, Doetschman T, Groden JL, Dove WF, Threadgill DW, Yeatman T, Coffey Jr RJ and Aronow BJ. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol 2007, 8(7):R131. PDF
2006
Jessen WJ, Hoose SA, Kilgore JA and Kladde MP. Active PHO5 chromatin encompasses a variable number of nucleosomes at individual promoters. Nat Struct Mol Biol 2006, 13(3):256-263. PDF
2004
Jessen WJ, Dhasarathy A, Hoose SA, Carvin CD, Risinger AL and Kladde MP. Mapping chromatin structure in vivo using DNA methyltransferases. Methods 2004, 33(1):68-80. PDF
2003
Carvin CD, Dhasarathy A, Friesenhahn LB, Jessen WJ and Kladde MP. Targeted cytosine methylation for in vivo detection of protein-DNA interactions. Proc Natl Acad Sci USA 2003, 100(13):7743-7748. PDF
Magazine Articles
2010
Jessen W. Medicine 2.0 and Participatory Medicine. Kidney News 2010, 2(6):10. PDF
Book Chapters
2007
Comstock CES, Burd CJ, Jessen WJ and Knudsen KE: Gene profiling analysis of androgen receptor mediated function. In Contemporary Endocrinology: Genomics in Endocrinology, DNA Microarray Analysis in Endocrine Health and Disease. Edited by Handwerger S and Aronow B. New Jersey: Humana Press Inc.; 2007:36.
Kilgore JA, Hoose SA, Dhasarathy A, Neef DW, Jessen WJ and Kladde MP: Dynamic chromatin remodeling at the budding yeast PHO5 promoter. In DNA Structure, Chromatin and Gene Expression. Edited by Kiyama R and Shimizu M. India: Research Signpost, 2007:101-120.
